Compagno J
Laryngoscope. 1978 Mar;88(3):460-9. doi: 10.1288/00005537-197803000-00010.
This study compares the published clinical and pathological features of hemangiopericytoma-like intranasal tumors with those of the hemangiopericytomas of other sites. Hemangiopericytoma-like intranasal tumors often originate in a paranasal sinus and extend into the nasal cavity secondarily. They occur most commonly in adults in the sixth and seventh decades of life and clinically mimic allergic polyps. These patients most commonly present with symptoms of nasal obstruction and epistaxis. Microscopically, these tumors demonstrate a vascular architecture, are composed predominantly of spindle cells, and lack nuclear or cytoplasmic pleomorphism, mitotic activity, hemorrhage, or necrosis. Follow-up data suggest that these tumors are unaggressive and are of local consequence only. Hemangiopericytomas of soft tissues usually occur in the retroperitoneum or the thigh and are uncommon in the nasal and paranasal sinuses. They usually present as painless masses. Attention to certain microscopic features of these tumors has led to reasonably good predictions of their behavior based on strict adherence to microscopic criteria. These criteria include the presence or absence of mitotic figures, necrosis, anaplasia, and hemorrhage.
本研究比较了鼻腔血管外皮细胞瘤样肿瘤已发表的临床和病理特征与其他部位血管外皮细胞瘤的特征。鼻腔血管外皮细胞瘤样肿瘤常起源于鼻窦，继而延伸至鼻腔。它们最常见于60和70岁的成年人，临床上类似过敏性息肉。这些患者最常见的症状是鼻塞和鼻出血。显微镜下，这些肿瘤显示出血管结构，主要由梭形细胞组成，且无核或胞质多形性、有丝分裂活性、出血或坏死。随访数据表明，这些肿瘤生长不活跃，仅具有局部影响。软组织血管外皮细胞瘤通常发生于腹膜后或大腿，在鼻腔和鼻窦中并不常见。它们通常表现为无痛性肿块。关注这些肿瘤的某些微观特征，基于严格遵循微观标准，已能对其行为做出较为准确的预测。这些标准包括有无有丝分裂象、坏死、间变和出血。
