Chipman J J, Boyar R M, Fink C W
J Rheumatol. 1982 Jan-Feb;9(1):63-8.
The hypothesis that gold therapy enhances endogenous cortisol secretion was tested in juvenile rheumatoid arthritis patients. The secretion of cortisol, dehydroepiandrosterone-sulfate (DHEA-S) and several peptide hormones was determined from plasma samples collected every 20 min for 24 hours. In random patients cortisol secretion was significantly greater in gold treated patients than in similar patients not receiving gold. However, when untreated patients were restudied after initiation of gold therapy, there was no significant change in cortisol secretion. Gold therapy also did not significantly alter secretion of the peptide hormones or DHEA-S. Thus, gold does not appear to influence endogenous hormone secretion.
在青少年类风湿性关节炎患者中测试了金疗法增强内源性皮质醇分泌的假说。每20分钟采集一次血浆样本，共采集24小时，以测定皮质醇、硫酸脱氢表雄酮（DHEA-S）和几种肽类激素的分泌情况。在随机分组的患者中，接受金治疗的患者的皮质醇分泌显著高于未接受金治疗的类似患者。然而，当未治疗的患者在开始金疗法后再次接受研究时，皮质醇分泌没有显著变化。金疗法也没有显著改变肽类激素或DHEA-S的分泌。因此，金似乎不会影响内源性激素的分泌。
