Fillastre J P, Ings R M, Leroy A, Godin M, Humbert G
Nephrologie. 1982;3(1):12-8.
The study was done after a single dose in 6 normal subjects and 24 patients with varying degrees of renal insufficiency. In normal subjects, the results are similar whatever the assays are used. In uremic patients, the half-life for the terminal phase increased with renal failure with the microbioassay, but it is demonstrated that deacetyl cefotaxime has only a prolonged half - life with a more specific assay = HPLC method. After repetitive doses, the tendency for accumulation was only noted in patients with very severe renal failure (creatinine clearance less than 5 ml.min-1).
该研究在6名正常受试者和24名不同程度肾功能不全患者单次给药后进行。在正常受试者中，无论使用何种检测方法，结果相似。在尿毒症患者中，微生物检测法显示，终末相半衰期随肾衰竭加重而延长，但已证实去乙酰头孢噻肟仅在更特异的检测方法（高效液相色谱法）下有延长的半衰期。重复给药后，仅在严重肾衰竭（肌酐清除率小于5 ml·min⁻¹）患者中观察到蓄积倾向。
