Cain C R, Simmonds M A
Neuropharmacology. 1982 Apr;21(4):371-3. doi: 10.1016/0028-3908(82)90103-4.
Baclofen has been shown to be ineffective against first order excitatory synaptic transmission in the olfactory cortex slice, whereas it is known that GABA-mediated inhibition depresses this transmission in a bicuculline-sensitive manner. In contrast, second and third order synaptic transmission, excitatory and inhibitory respectively, were depressed by baclofen. This suggests that the distribution of baclofen (GABAB) receptors differs from that of bicuculline-sensitive GABAA receptors in the olfactory cortex.
巴氯芬已被证明对嗅皮质切片中的一级兴奋性突触传递无效，而众所周知，γ-氨基丁酸（GABA）介导的抑制作用以荷包牡丹碱敏感的方式抑制这种传递。相比之下，巴氯芬抑制了二级和三级突触传递，分别为兴奋性和抑制性。这表明巴氯芬（GABAB）受体的分布与嗅皮质中荷包牡丹碱敏感的GABAA受体的分布不同。
