Effects of baclofen on the olfactory cortex slice preparation.

Baclofen has been shown to be ineffective against first order excitatory synaptic transmission in the olfactory cortex slice, whereas it is known that GABA-mediated inhibition depresses this transmission in a bicuculline-sensitive manner. In contrast, second and third order synaptic transmission, excitatory and inhibitory respectively, were depressed by baclofen. This suggests that the distribution of baclofen (GABAB) receptors differs from that of bicuculline-sensitive GABAA receptors in the olfactory cortex.