大鼠阿片促黑皮质素含有硫酸盐。
Rat pro-opiomelanocortin contains sulfate.
作者信息
Hoshina H, Hortin G, Boime I
出版信息
Science. 1982 Jul 2;217(4554):63-4. doi: 10.1126/science.6283633.
PMID:6283633
Abstract
Intermediate lobes isolated from rat pituitary glands incorporated [35S]sulfate into pro-opiomelanocortin and other adrenocorticotropic hormone-containing peptides. Incubation of intermediate lobes in medium containing the arginine analog canavanine inhibited the cleavage of pro-opiomelanocortin into smaller products. Pro-opiomelanocortin that accumulated in the presence of canavanine was also sulfated.
摘要
从大鼠垂体分离出的中间叶将[35S]硫酸盐掺入促肾上腺皮质激素原和其他含促肾上腺皮质激素的肽中。在含有精氨酸类似物刀豆氨酸的培养基中培养中间叶，可抑制促肾上腺皮质激素原裂解为较小的产物。在刀豆氨酸存在下积累的促肾上腺皮质激素原也被硫酸化。
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