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[乳腺癌的外科治疗——30年经验]

[Surgical treatment of breast carcinoma - 30 years' experience].

作者信息

Dukić V, Milićević M, Dugalić D, Lekić S, Subotić S, Radović Z

出版信息

Acta Chir Iugosl. 1982;29(1):61-71.

PMID:6283775
Abstract

Although, carcinoma of the breast, because of its high frequency and many specific properties, belongs to the most studied of malignancies, it remains a fact that during the past 3 decades the incidence of mortality from this disease has changed little. The authors, drawing on their 30 years experience, demonstrate that the mortality rate and the survival rate depend on the kind of surgical intervention as well as the stage of development of the disease at the moment of operation. For this purpose a total of 655 operated cases were recorded (643 female and 12 male) using the Steinthal classification. In this series 68.1% were infertile; the upper outer quadrant was affected in 54% of cases; histologically the most frequent form was scirrhous adenocarcinoma. The greatest number of patients belonged to stage II and III, whereas the average time from the appearance of the first symptoms up to the medical examination was 6-12 months. Further spread of the disease and regional metastases were presented in more than 65% of cases. It was demonstrated that surgical procedure used depended on the extensiveness of the disease; modified radical mastectomy was performed in 54.2% of patients and Halsted's radical mastectomy in 40.15%. 185 patients were given the control examination. A strictly statistical analysis of the results confirmed that whereas the length of survival was not significantly affected by the kind of operation, the mortality rate did vary according to which surgical procedure was used. The author conclude that there is no best or unique surgical method and that each patient should be examined in a multidisciplinary way, and his treatment should be carefully planned.

摘要

尽管乳腺癌因其高发性和诸多特性,属于研究最多的恶性肿瘤之一,但在过去30年里,该疾病的死亡率几乎没有变化,这仍是一个事实。作者凭借其30年的经验表明,死亡率和生存率取决于手术干预的类型以及手术时疾病的发展阶段。为此,采用施泰因塔尔分类法记录了总共655例手术病例(643例女性和12例男性)。在这个系列中,68.1%的患者不育;54%的病例病变位于上外象限;组织学上最常见的类型是硬癌性腺癌。大多数患者属于II期和III期,而从首次出现症状到进行医学检查的平均时间为6至12个月。超过65%的病例出现了疾病的进一步扩散和区域转移。结果表明,所采用的手术方式取决于疾病的范围;54.2%的患者进行了改良根治性乳房切除术,40.15%的患者进行了霍尔斯特德根治性乳房切除术。对185名患者进行了对照检查。对结果进行的严格统计分析证实,虽然手术方式对生存时间没有显著影响,但死亡率确实因所采用的手术程序而异。作者得出结论,不存在最佳或唯一的手术方法,每个患者都应接受多学科检查,并应仔细规划其治疗方案。

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