Souhami R L, Harper P G, Linch D, Trask C, Goldstone A H, Tobias J, Spiro S G, Geddes D M, Richards J D
Cancer Chemother Pharmacol. 1982;8(1):31-4. doi: 10.1007/BF00292868.
Sixteen patients with untreated small cell carcinoma of the bronchus received cyclophosphamide in a total dose of 160-200 mg/kg. Autologous marrow transplantation was used to minimise the period of hypoplasia and 2-mercaptoethane sulphonate to prevent urothelial toxicity. The procedure was well tolerated, with predictable and manageable toxicity. Complete radiological and bronchoscopic response was achieved in seven patients and partial response in a further seven. High-dose cyclophosphamide may be a useful initial treatment for this disease.
16例未经治疗的支气管小细胞癌患者接受了总量为160 - 200mg/kg的环磷酰胺治疗。采用自体骨髓移植以尽量缩短发育不全期，并使用2-巯基乙烷磺酸盐预防尿路上皮毒性。该治疗方法耐受性良好，毒性可预测且可控。7例患者实现了影像学和支气管镜检查完全缓解，另有7例部分缓解。高剂量环磷酰胺可能是该疾病一种有效的初始治疗方法。
