Hui K K, Wolfe R N, Conolly M E
Clin Pharmacol Ther. 1982 Aug;32(2):161-5. doi: 10.1038/clpt.1982.142.
Binding of (-)3H]-dihydroalprenolol (3H-DHA) to lymphocytes from five thyrotoxic patients and five age- and sex-matched contents were examined to ascertain whether beta-adrenergic receptor number or binding affinity were altered in thyrotoxicosis. Whereas an increase in beta-adrenoceptor density has been reported in triiodothyronine-induced hyperthyroidism, we did not find changes in beta-adrenergic receptor density or binding affinity. In one patient studied sequentially, we did not find alteration in 3H-DHA bindings before or after the subject was rendered euthyroid. We conclude that lymphocyte beta-adrenergic receptor density and affinity are not altered in spontaneous hyperthyroidism.
检测了5例甲状腺毒症患者及5例年龄和性别匹配的对照者淋巴细胞对[(-)³H]-二氢烯丙洛尔（³H-DHA）的结合情况，以确定甲状腺毒症时β-肾上腺素能受体数量或结合亲和力是否发生改变。虽然已有报道称三碘甲状腺原氨酸诱导的甲状腺功能亢进症中β-肾上腺素能受体密度增加，但我们未发现β-肾上腺素能受体密度或结合亲和力有变化。在1例接受序贯研究的患者中，在该患者甲状腺功能恢复正常之前或之后，我们均未发现³H-DHA结合有改变。我们得出结论，自发性甲状腺功能亢进症时淋巴细胞β-肾上腺素能受体密度和亲和力未发生改变。
