Schoffelmeer A N, Mulder A H
Eur J Pharmacol. 1982 Apr 23;79(3-4):329-32. doi: 10.1016/0014-2999(82)90642-2.
The inhibitory effects of morphine and Cd2+ on electrically evoked [3H]noradrenaline release from superfused brain slices were unaffected when release was enhanced by increasing the pulse duration, while the inhibitory effect of noradrenaline and the enhancing effect of phentolamine were diminished. A similar enhancement of [3H]noradrenaline release by 4-aminopyridine reduced the modulatory effects of all drugs examined. Therefore there seem to be different mechanisms for the effect of presynaptic alpha-adrenoceptors and opiate receptors on the availability of Ca2+ for the stimulus-secretion coupling process in noradrenergic nerve terminals.
当通过增加脉冲持续时间来增强释放时，吗啡和镉离子对从灌流脑片中电诱发的[³H]去甲肾上腺素释放的抑制作用未受影响，而去甲肾上腺素的抑制作用和酚妥拉明的增强作用则减弱。4-氨基吡啶对[³H]去甲肾上腺素释放的类似增强作用降低了所有所检测药物的调节作用。因此，对于去甲肾上腺素能神经末梢中突触前α-肾上腺素能受体和阿片受体对刺激-分泌偶联过程中钙离子可用性的影响，似乎存在不同的机制。
