[Effect of blockers of pre- and post-synaptic inhibition on processes of habituation in the system of cutaneous sensitivity].

The role of pre- and postsynaptic inhibition in the habituation of spinal ascending neurons transmitting cutaneous sensory signals was studied in cat. Pharmacological blockade of these types of inhibition by strychnine, bicuculline and picrotoxin did not evoke substantial changes in initial suppression of neuronal discharges during prolonged high-frequency (more than 50 per s) stimulation. Neuronal responses to stimulation of a cutaneous nerve fibres were not influenced during habituation of the neuron evoked by stimulation of other converging cutaneous nerve fibres.