Hatam A, Yu Z Y, Bergström M, Berggren B M, Greitz T
J Comput Assist Tomogr. 1982 Jun;6(3):586-92. doi: 10.1097/00004728-198206000-00025.
In a prospective study, the effect of dexamethasone treatment on brain edema was evaluated by computed tomography (CT) in 14 patients with intracranial neoplasm. A CT study was made immediately prior to the beginning of the treatment and at various intervals for 8 to 19 days thereafter. The volume and attenuation of the edema were measured and related to the time after the start of treatment. In five cases of meningioma, only minor changes were shown; the edema volume either decreased or increased slightly or did not change at all. In four gliomas, a substantial decrease was noted in the edema volume in two cases and a smaller decrease was observed in two cases. In three metastases, a linear decrease in edema volume was noted during the entire follow-up, reducing it to one-fourth of the initial volume after 2 weeks of treatment. In one case of acoustic neuroma and in one undiagnosed lesion, a marked decrease in edema volume was also noted. The attenuation of the remaining edema was constant during the entire treatment time.
在一项前瞻性研究中，通过计算机断层扫描（CT）对14例颅内肿瘤患者评估了地塞米松治疗对脑水肿的影响。在治疗开始前及之后8至19天的不同时间间隔进行了CT检查。测量了水肿的体积和衰减程度，并将其与治疗开始后的时间相关联。在5例脑膜瘤患者中，仅显示出轻微变化；水肿体积要么略有减少或增加，要么根本没有变化。在4例胶质瘤患者中，2例水肿体积显著减少，2例减少较小。在3例转移瘤患者中，在整个随访期间水肿体积呈线性下降，治疗2周后降至初始体积的四分之一。在1例听神经瘤和1例未确诊病变中，也观察到水肿体积明显减少。在整个治疗期间，剩余水肿的衰减程度保持不变。
