肾脏白蛋白排泄：渗透性利尿的影响。
Albumin excretion by the kidney: the effects of osmotic diuresis.
作者信息
First M R, Patel V B, Pesce A J, Bramlage R J, Pollak V E
出版信息
Nephron. 1978;20(3):171-5. doi: 10.1159/000181216.
Urine albumin excretion rate in female Sprague-Dawley rats was measured duing a stable period of normal hydration and following mannitol-induced osmotic diuresis. Mannitol infusion resulted in a significant increase in urine volume and fractional excretion of sodium, but glomerular filtration rate, albumin excretion rate, and the sieving coefficient for albumin remained stable. The results suggest that under physiological conditions, changes in albumin excretion are dependent upon changes in glomerular filtration rather than urine flow.
在正常水合稳定期以及甘露醇诱导的渗透性利尿后，测量雌性Sprague-Dawley大鼠的尿白蛋白排泄率。输注甘露醇导致尿量和钠分数排泄显著增加，但肾小球滤过率、白蛋白排泄率和白蛋白筛滤系数保持稳定。结果表明，在生理条件下，白蛋白排泄的变化取决于肾小球滤过的变化而非尿流。
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