恶性胶质瘤患者免疫能力受损：T 淋巴细胞亚群的可能作用。

Impaired immunocompetence in patients with malignant gliomas: the possible role of Tg-lymphocyte subpopulations.

作者信息

Gerosa M A, Olivi A, Rosenblum M L, Semenzato G P, Pezzutto A

出版信息

Neurosurgery. 1982 May;10(5):571-3. doi: 10.1227/00006123-198205000-00004.

DOI:10.1227/00006123-198205000-00004

Abstract

T-lymphocyte subpopulations (Tg or "suppressor cells" and Tm or "helper cells") in the peripheral blood of 16 patients with malignant intracranial gliomas were analyzed. The number of Tm-lymphocytes was very close to normal in both pre- and postoperative samples, whereas Tg-lymphocytes were significantly increased preoperatively (18.55 +/- 1.11 vs. 12.72 +/- 1.19 p less than 0.001) and were still slightly higher than normal after operation and radiation treatment. These preliminary findings suggest a possible role of T-suppressor lymphocytes in the impairment of cell-mediated immunocompetence that has been observed repeatedly in patients with malignant gliomas.

摘要

对16例恶性颅内胶质瘤患者外周血中的T淋巴细胞亚群（Tg或“抑制细胞”和Tm或“辅助细胞”）进行了分析。术前和术后样本中Tm淋巴细胞的数量均非常接近正常水平，而Tg淋巴细胞在术前显著增加（18.55±1.11对12.72±1.19，p<0.001），在手术和放疗后仍略高于正常水平。这些初步发现表明，T抑制淋巴细胞可能在恶性胶质瘤患者中反复观察到的细胞介导免疫能力损害中发挥作用。