[Changes in the function of the hypothalamo-hypophyseo-adrenal system and the thymus as affected by corticotropin in guinea pigs].

Functional state of the hypothalamic-hypophyseal-adrenal system and the thymus was studied in thymic hypo- and hyperplasia of guinea pigs. It was detected that thymomegalia is accompanied by STH and prolactin hyperproduction in adeno-hypophysis, intensified lymphopoiesis (at the expense of T-lymphocytes) and the adrenal glucocorticoid function inhibition, resultant of the lowered ACTH secretion, as well as by the enhanced catecholamine and serotonin content in the hypothalamus. Reverse changes are seen in thymic hypoplasia following intramuscular ACTH injection in a dose 1 U/kg/day within 5 to 10 days.