Shcherbakova E G, Vyrenko Iu E, Zhuravleva T P, Vazilo V E, Rastunova G A
Antibiotiki. 1982 May;27(5):359-64.
Distribution of gentamycin and klaforan in the lymphatic system, blood and cerebrospinal fluid, as well as their effect on lymph node morphology was studied experimentally on 46 dogs. The antibiotics were administered endolymphatically in doses of 1 and 30 mg/kg respectively. The highest levels of gentamycin (200-250 micrograms/ml) and klaforan (up to 1600 micrograms/ml) were detected in the central lymph. The therapeutic levels of the antibiotics in the central persisted for 24 and 72 hours respectively. The antibiotics accumulated mainly in the regional (inguinal and pelvic) lymph nodes, where their high levels were determined for 72 hours. The levels of the antibiotics in the distant (cervical and tracheobronchial) lymph nodes were lower and did not exceed the therapeutic ones. They persisted for 6 and 24 hours respectively. No unfavourable effect of the antibiotics on the structure and cell composition of the lymph nodes was noted. After endolymphatic administration in the above doses the antibiotic levels in the blood serum were close to those observed after administration by the routine routes. After endolymphatic administration in the above doses the antibiotics penetrated into the cerebrospinal fluid.
在46只狗身上进行了实验研究，观察庆大霉素和头孢菌素在淋巴系统、血液及脑脊液中的分布情况，以及它们对淋巴结形态的影响。分别以1毫克/千克和30毫克/千克的剂量经内淋巴途径给予抗生素。在中央淋巴中检测到庆大霉素的最高水平为200 - 250微克/毫升，头孢菌素的最高水平达1600微克/毫升。抗生素在中央淋巴中的治疗水平分别持续24小时和72小时。抗生素主要积聚在局部（腹股沟和盆腔）淋巴结中，其高水平在这些淋巴结中持续72小时。远处（颈部和气管支气管）淋巴结中的抗生素水平较低，未超过治疗水平，分别持续6小时和24小时。未观察到抗生素对淋巴结结构和细胞组成有不良影响。按上述剂量经内淋巴给药后，血清中的抗生素水平与常规途径给药后观察到的水平相近。按上述剂量经内淋巴给药后，抗生素可穿透进入脑脊液。
