Feldon S E, Stark L, Lehman S L, Hoyt W F
Arch Neurol. 1982 Aug;39(8):497-503. doi: 10.1001/archneur.1982.00510200039007.
Five abnormal oculographic patterns were identified in eight patients with either myasthenia gravis or Guillain-Barré syndrome (GBS). These could be differentiated into three intrasaccadic and two postsaccadic abnormalities. From our studies of computer simulations, and considering the established pathophysiology of myasthenia gravis and GBS, we believe that our oculographic findings were a consequence of defects in peripheral neural and neuromuscular conduction, together with a simple adaptive increase in duration of the saccadic burst of central innervation. We conclude that the eye movement abnormalities we observed are explained by intermittent block of peripheral conduction, and suggest that any disease causing intermittent blockage of neural signals to extraocular muscles will produce similar abnormalities of eye movement.
在8例重症肌无力或吉兰-巴雷综合征（GBS）患者中识别出5种异常眼动图模式。这些模式可分为3种扫视内异常和2种扫视后异常。通过我们的计算机模拟研究，并考虑到重症肌无力和GBS已确定的病理生理学，我们认为我们的眼动图发现是外周神经和神经肌肉传导缺陷的结果，同时中央神经支配的扫视爆发持续时间有一个简单的适应性增加。我们得出结论，我们观察到的眼动异常是由外周传导的间歇性阻滞所解释的，并表明任何导致眼外肌神经信号间歇性阻滞的疾病都会产生类似的眼动异常。
