通过激活艾氏腹水癌细胞中依赖Ca2+的K+通道来刺激依赖Na+的氨基酸摄取。
Stimulation of Na+ -dependent amino acid uptake by activation of the Ca2+ -dependent K+ channel in the Ehrlich ascites tumor cell.
作者信息
Valdeolmillos M, García-Sancho J, Herreros B
出版信息
Biochim Biophys Acta. 1982 Jul 14;689(1):177-9. doi: 10.1016/0005-2736(82)90204-8.
PMID:6285975
Abstract
The activation of Ca2+ -dependent K+ channel by propranolol or by ascorbate-phenazine methosulphate stimulates Na+ -dependent transport of alpha-aminoisobutyric acid. This stimulation arises from a membrane hyperpolarization due to the specific increase of membrane K+ conductance. The same treatment does not modify the Na+ -independent uptake of the norbornane amino acid.
摘要
普萘洛尔或抗坏血酸 - 吩嗪硫酸甲酯对钙依赖性钾通道的激活可刺激α-氨基异丁酸的钠依赖性转运。这种刺激源于膜钾电导的特异性增加导致的膜超极化。相同处理不会改变降冰片烷氨基酸的非钠依赖性摄取。
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