Bichard A R, Little H J
Br J Pharmacol. 1982 Jul;76(3):447-52. doi: 10.1111/j.1476-5381.1982.tb09238.x.
1 The effects on the high pressure neurological syndrome (HPNS) of drugs which facilitate gamma-aminobutyric acid (GABA) transmission were investigated. Threshold pressures for the onset of the behavioural signs of the HPNS in mice--tremors and convulsions were established. 2 Flurazepam hydrochloride 20 and 10 mg/kg and sodium valproate 800 and 400 mg/kg substantially raised the threshold pressures for both tremor and convulsions. 3 Amino-oxyacetic acid 35 and 25 mg/kg and diaminobutyric acid 600 mg/kg also significantly increased the thresholds. Muscimol 1 mg/kg (and 150 ng i.c.v.) was ineffective at non-toxic doses. 4 These effects paralleled the drugs' ability to raise the convulsion threshold to intravenous infusion of bicuculline in mice. 5 These results demonstrate that drugs with actions more selective than those of the general anaesthetics are effective against the HPNS. It is also possible that there is a GABAergic component to the effects of general anaesthetics on the HPNS.
1 研究了促进γ-氨基丁酸（GABA）传递的药物对高压神经综合征（HPNS）的影响。确定了小鼠中HPNS行为体征（震颤和惊厥）发作的阈压。2 盐酸氟西泮20和10mg/kg以及丙戊酸钠800和400mg/kg显著提高了震颤和惊厥的阈压。3 氨基氧乙酸35和25mg/kg以及二氨基丁酸600mg/kg也显著提高了阈压。毒蝇蕈醇1mg/kg（以及脑室内注射150ng）在无毒剂量下无效。4 这些作用与药物提高小鼠静脉注射荷包牡丹碱惊厥阈值的能力平行。5 这些结果表明，作用比全身麻醉药更具选择性的药物对HPNS有效。全身麻醉药对HPNS的作用也可能存在GABA能成分。
