氯胺酮及高压对大鼠离体颈上神经节γ-氨基丁酸反应的影响
Effects of ketamine and of high pressure on the responses to gamma-aminobutyric acid of the rat superior cervical ganglion in vitro.
作者信息
Little H J
出版信息
Br J Pharmacol. 1982 Oct;77(2):209-16. doi: 10.1111/j.1476-5381.1982.tb09287.x.
Abstract
1 The method of Brown & Marsh (1974) for recording of surface potentials from the rat superior cervical ganglion has been adapted for use in a high pressure chamber in order to study the effects of high pressure of helium and the possible interactions with the effects of general anaesthetics. 2 Helium pressure of 130 atm did not alter the amplitude of the responses recorded from the ganglion in response to gamma-aminobutyric acid (GABA) application (9.7 and 19.4 microM) but the amplitude of responses to a nicotinic agonist were depressed. 3 Ketamine, at concentration between 18 and 180 microM, considerably potentiated the responses of the ganglion to GABA. 4 Helium pressure (130 atm) did not reverse the potentiation of GABA by ketamine. 5 The results are discussed in connection with the ability of ketamine to oppose the behavioural effects of high pressure.
摘要
- 布朗和马什（1974年）记录大鼠颈上神经节表面电位的方法已被改编用于高压舱，以研究氦气高压的影响以及与全身麻醉药作用可能存在的相互作用。2. 130个大气压的氦气压力并未改变神经节在应用γ-氨基丁酸（GABA，9.7和19.4微摩尔）时记录到的反应幅度，但对烟碱激动剂的反应幅度降低。3. 氯胺酮浓度在18至180微摩尔之间时，显著增强了神经节对GABA的反应。4. 氦气压力（130个大气压）并未逆转氯胺酮对GABA的增强作用。5. 结合氯胺酮对抗高压行为影响的能力对结果进行了讨论。
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