人及猪肺实质条中β-肾上腺素能受体的比较研究
A comparative study of beta-adrenoceptors in human and porcine lung parenchyma strip.
作者信息
Goldie R G, Paterson J W, Wale J L
出版信息
Br J Pharmacol. 1982 Aug;76(4):523-6. doi: 10.1111/j.1476-5381.1982.tb09249.x.
Abstract
- Responses to (+/-)-isoprenaline (Iso), (-)-adrenaline (Adr) and (-)-noradrenaline (NA) were compared in isolated preparations of human and porcine lung parenchyma strip. 2. The order of relaxant potencies of these catecholamines in both human and porcine lung parenchyma was Iso greater than Adr greater than NA (1:0.24:0.01, human; 1:0.21:0.01.pig). These results suggest that beta 2-adrenoceptors predominate in both types of lung parenchyma strip. 3. pA2 values for the beta-adrenoceptor antagonist, propranolol (non-selective), with Iso as the agonist, in human and porcine lung strips were 7.84 and 7.83 respectively and for atenolol were 6.50 and 5.35 respectively. Taken as a whole results indicate the existence of an apparently homogeneous population of beta 2-adrenoceptors in porcine parenchyma strip, while both beta 1 and beta 2-adrenoceptors were revealed in human lung parenchyma.
摘要
- 在人及猪肺实质条带的离体标本中比较了对（±）-异丙肾上腺素（Iso）、（-）-肾上腺素（Adr）和（-）-去甲肾上腺素（NA）的反应。2. 这些儿茶酚胺在人及猪肺实质中的舒张效能顺序为Iso＞Adr＞NA（人：1:0.24:0.01；猪：1:0.21:0.01）。这些结果提示β2-肾上腺素受体在两种类型的肺实质条带中占主导。3. 以Iso为激动剂时，β-肾上腺素受体拮抗剂普萘洛尔（非选择性）在人及猪肺条带中的pA2值分别为7.84和7.83，阿替洛尔的pA2值分别为6.50和5.35。总体而言，结果表明猪实质条带中存在明显均一的β2-肾上腺素受体群体，而人肺实质中同时显示出β1和β2-肾上腺素受体。
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本文引用的文献
1
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2
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Res Commun Chem Pathol Pharmacol. 1980 Jul;29(1):15-25.
3
Catecholamine transport in isolated lung parenchyma of pig.猪离体肺实质中的儿茶酚胺转运
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4
Characterization of the beta-adrenoceptors in guinea-pig lung mast cells [proceedings].豚鼠肺肥大细胞中β-肾上腺素能受体的特性[会议论文集]
Br J Pharmacol. 1980 Jan;68(1):152P.
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6
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