溴化乙锭对烟碱型乙酰胆碱受体的影响。
Effects of ethidium bromide on the nicotinic acetylcholine receptor.
作者信息
Sterz R, Hermes M, Peper K, Bradley R J
出版信息
Eur J Pharmacol. 1982 Jun 4;80(4):393-9. doi: 10.1016/0014-2999(82)90085-1.
PMID:6286326
Abstract
Ethidium bromide was tested for electrophysiological effects at the postsynaptic membrane of the frog muscle endplate. At low concentrations ethidium bromide blocked the open ion channel of the nicotinic acetylcholine receptor and reduced its open time. The rates for channel blocking and unblocking were calculated giving a dissociation constant of 139 nM at -80 mV membrane potential.
摘要
对溴化乙锭在青蛙肌肉终板突触后膜上的电生理效应进行了测试。在低浓度下，溴化乙锭会阻断烟碱型乙酰胆碱受体的开放离子通道并缩短其开放时间。计算了通道阻断和解阻速率，得出在膜电位为 -80 mV 时的解离常数为 139 nM。
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