Travis E L, De Luca A M, Fowler J F, Padikal T N
Int J Radiat Oncol Biol Phys. 1982 May;8(5):843-50. doi: 10.1016/0360-3016(82)90087-6.
The radioprotective effect of 400 mg/kg of WR 2721 on mouse skin has been investigated over a series of times from 5 to 60 minutes after intravenous or intraperitoneal injection of the drug. The acute desquamation reaction on the hind leg of white mice was studied. Dose response curves were obtained for the average reaction over 15 to 25 days after single-dose irradiation. A high dose-rate electron beam (13--17 Gy/min) was used to minimize the irradiation time. Single doses of 20 to 60 grays were given. Dose modifying factors (DMFs) of 1.7--2.1 were obtained at 30 to 60 minutes, but only 1.1 to 1.3 at 5 minutes and intermediate values at 10 and 15 minutes. DMFs rose slightly faster and to slightly higher values after i.v. than after i.p. injection of WR 2721. We conclude that 30 minutes is the shortest interval which should be used between injection of Wr 2721 and irradiation with this normal tissue.
研究了静脉或腹腔注射400mg/kg的WR 2721后5至60分钟内对小鼠皮肤的辐射防护作用。对白鼠后腿的急性脱屑反应进行了研究。获得了单剂量照射后15至25天平均反应的剂量反应曲线。使用高剂量率电子束（13-17Gy/分钟）以尽量缩短照射时间。给予20至60格雷的单剂量。在30至60分钟时获得的剂量修正因子（DMF）为1.7-2.1，但在5分钟时仅为1.1至1.3，在10和15分钟时为中间值。静脉注射WR 2721后，DMF上升略快且值略高。我们得出结论，30分钟是注射WR 2721与对该正常组织进行照射之间应使用的最短间隔时间。
