Adachi T, Odagiri E, Shirota M, Shinozaki H, Jibiki K, Demura R, Demura H, Shizume K, Murayama K, Oouchi H
Nihon Sanka Fujinka Gakkai Zasshi. 1982 Jul;34(7):945-53.
To evaluate the effects of oxytocics on ACTH and Immunoreactive (IR)-beta-endorphin release, concentrations of these hormones in the plasma of 22 women during spontaneous labor, 22 women in labor who had received oxytocin and 19 women in labor who had received PG.F2 alpha at the time of vaginal delivery, were measured. Maternal ACTH and IR-beta-endorphin concentrations were elevated during spontaneous or oxytocics induced/maintained labor and peaked immediately after delivery and decreased two hours later. There were significant correlations between ACTH and IR-beta-endorphin concentrations during spontaneous labor and delivery (r = 0.921, p less than 0.0001), as well as in oxytocin or PG.F2 alpha induced/maintained labor and delivery (r = 0.833, r = 0.916, p less than 0.0001, respectively). The concentrations of ACTH and IR-beta-endorphin during PG-F2 alpha infusion were slightly higher than those seen in the other two types of labor. However, there was no significant difference in the levels of ACTH and IR-beta-endorphin among the three types of labor. Simultaneous maternal and umbilical cord plasma samples were obtained in 25 cases at delivery. However, there was no significant correlation between ACTH or IR-beta-endorphin concentrations in paired samples. These results suggest that 1) IR-beta-endorphin is secreted in parallel with ACTH, into the peripheral blood by the maternal pituitary gland in response to the stress of labor during all types of labor and delivery; 2) there is no significant difference in the response of ACTH and IR-beta-endorphin between spontaneous and oxytocics induced/maintained labor and delivery: 3) ACTH and IR-beta-endorphin in cord blood are not of maternal origin.
为评估宫缩剂对促肾上腺皮质激素（ACTH）及免疫反应性（IR）-β-内啡肽释放的影响，对22例自然分娩的产妇、22例接受催产素的产妇及19例在阴道分娩时接受前列腺素F2α（PG.F2α）的产妇，测定其分娩时血浆中这些激素的浓度。产妇ACTH及IR-β-内啡肽浓度在自然分娩或宫缩剂诱导/维持的分娩过程中升高，在分娩后即刻达到峰值，两小时后下降。自然分娩及分娩过程中ACTH与IR-β-内啡肽浓度之间存在显著相关性（r = 0.921，p < 0.0001），在催产素或PG.F2α诱导/维持的分娩及分娩过程中也存在显著相关性（分别为r = 0.833，r = 0.916，p < 0.0001）。PG-F2α输注期间ACTH及IR-β-内啡肽的浓度略高于其他两种分娩类型。然而，三种分娩类型中ACTH及IR-β-内啡肽水平无显著差异。25例产妇在分娩时同时采集了母体和脐带血浆样本。然而，配对样本中ACTH或IR-β-内啡肽浓度之间无显著相关性。这些结果表明：1）在所有类型的分娩及分娩过程中，IR-β-内啡肽与ACTH平行分泌，由母体垂体释放至外周血，以应对分娩应激；2）自然分娩与宫缩剂诱导/维持的分娩及分娩过程中，ACTH和IR-β-内啡肽反应无显著差异；3）脐血中的ACTH和IR-β-内啡肽并非来自母体。
