Gillespie J I, Meves H
J Physiol (Paris). 1981 May;77(9):1087-92.
Inactivation of the Na permeability has been studied in intact and perfused squid giant axons with the voltage clamp method. The main results are: 1. Upon depolarization inactivation develops along an exponential time course; the upper limit for an initial delay in the development of inactivation is 50-100 musec. 2. Adding 20-40 mM KCl to K-free external solution accelerates the development of inactivation and slows its removal. 3. Scorpion venoms increase the maintained conductance, i.e. make inactivation less complete; the voltage dependence of the maintained conductance is different from that of the peak conductance.
利用电压钳技术，在完整的和经灌注的枪乌贼巨大轴突中研究了钠通透性的失活情况。主要结果如下：1. 去极化时，失活呈指数时间进程发展；失活发展初始延迟的上限为50 - 100微秒。2. 向无钾的外部溶液中添加20 - 40 mM氯化钾可加速失活的发展并减缓其消除。3. 蝎毒增加了持续电导，即使失活不那么完全；持续电导的电压依赖性与峰值电导的不同。
