Maurer R
Neurosci Lett. 1982 Jun 30;30(3):303-7. doi: 10.1016/0304-3940(82)90417-7.
Three populations of opiate binding sites (mu, delta and kappa) could be distinguished by displacement studies with the mu-agonist (D)-Ala2-MePhe4-Glyol5-enkephalin and the kappa-agonist 3H-bremazocine in brain membranes of different species. Whereas brain membranes from pig or guinea-pig and human cortical membranes had a proportion of approximately 35-50% kappa-, 29-40% mu-, and 21-30% delta-binding sites, rat membranes contained much less kappa-sites (12% kappa, 62% mu and 25% delta).
通过用μ-激动剂（D）-丙氨酸2-甲基苯丙氨酸4-甘醇5-脑啡肽和κ-激动剂[3H]-（-）-布马佐辛对不同物种的脑膜进行置换研究，可以区分出三种阿片样物质结合位点（μ、δ和κ）。猪或豚鼠的脑膜以及人类皮质脑膜中，κ结合位点约占35-50%，μ结合位点占29-40%，δ结合位点占21-30%，而大鼠脑膜中的κ位点则少得多（κ占12%，μ占62%，δ占25%）。
