甲喹酮对大鼠血浆皮质酮的影响：可能的作用位点。
Effect of methaqualone on plasma corticosterone in rats: possible sites of action.
作者信息
Boggan W O, Meyer J S
出版信息
Pharmacol Biochem Behav. 1982 Jun;16(6):925-7. doi: 10.1016/0091-3057(82)90046-6.
PMID:6287502
Abstract
Methaqualone produces large increases in plasma corticosterone in rats. This effect does not involve a direct stimulation of either the adrenal glands or pituitary, nor is it the result of a significant alteration in the clearance of circulating corticosterone. Methaqualone may therefore be influencing brain mechanisms which ultimately regulate hypothalamic CRH secretion, although a peripheral site of action has not yet been ruled out.
摘要
甲喹酮可使大鼠血浆皮质酮大幅增加。这种作用既不涉及对肾上腺或垂体的直接刺激，也不是循环皮质酮清除率显著改变的结果。因此，甲喹酮可能影响最终调节下丘脑促肾上腺皮质激素释放激素（CRH）分泌的脑机制，尽管尚未排除外周作用部位。
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