生物螯合作用：2,3-二巯基丙烷磺酸和内消旋二巯基琥珀酸。
Biological chelation: 2,3-dimercapto-propanesulfonic acid and meso-dimercaptosuccinic acid.
作者信息
Aposhian H V
出版信息
Adv Enzyme Regul. 1982;20:301-19. doi: 10.1016/0065-2571(82)90022-x.
PMID:6287818
Abstract
Water soluble analogs of British Anti-Lewisite that are active orally and less toxic than BAL are now available. These agents are 2,3-dimercapto-1-propanesulfonic acid and meso-dimercaptosuccinic acid. Evidence for their effectiveness in preventing the lethal effects of sodium arsenite in mice and lewisite in rabbits is presented. These analogs can be expected to replace BAL in the treatment of heavy metal poisoning.
摘要
现在已有英国抗路易氏剂的水溶性类似物，它们口服有效且毒性比二巯丙醇低。这些药剂是2,3-二巯基-1-丙烷磺酸和内消旋二巯基琥珀酸。文中给出了它们在预防小鼠亚砷酸钠中毒和兔子路易氏剂中毒致死效应方面有效性的证据。预计这些类似物将在重金属中毒治疗中取代二巯丙醇。
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