Oluboyede O A, Ajayi O A, Adeyokunnu A A
Afr J Med Med Sci. 1981 Mar-Jun;10(1-2):1-7.
The prevalence of iron deficiency anaemia during the first three decades of life was investigated in eighty-five patients with SS and SC haemoglobins. The parameters used were the haematocrit, serum iron, total iron binding capacity (TIBC), percentage saturation of transferrin and availability of iron in the bone marrow. The mean haematocrit values were similar throughout the three decades, but increased with age (r = 0.41). The mean serum iron was significantly lower (P less than 0.01) in the first decade than in the second or third decade. Females had lower serum iron in the first and second decades and higher values in the third decade than their male counterparts. The transferrin saturation was significantly lower (P less than 0.01) in the first decade than in the third decade. No haemosiderin was found in the marrow aspirates at a transferrin saturation of less than or equal to 15%. Of the eighty-five bone marrow aspirates studied for stainable iron, fifty-eight (68.2%) had nil iron. The data presented show that iron deficiency anaemia is a common finding in patients with haemoglobinopathies. The need to incorporate oral iron with folic acid and paludrine in the treatment of sickle cell disease is suggested.
对85例患有血红蛋白SS和SC的患者在生命的前三十年中缺铁性贫血的患病率进行了调查。所使用的参数有血细胞比容、血清铁、总铁结合力（TIBC）、转铁蛋白饱和度百分比以及骨髓中铁的可用性。在这三十年中，平均血细胞比容值相似，但随年龄增加（r = 0.41）。第一个十年的平均血清铁显著低于（P小于0.01）第二个或第三个十年。在第一个和第二个十年中，女性的血清铁低于男性，而在第三个十年中则高于男性。第一个十年的转铁蛋白饱和度显著低于（P小于0.01）第三个十年。转铁蛋白饱和度小于或等于15%时，骨髓穿刺物中未发现含铁血黄素。在研究可染色铁的85份骨髓穿刺物中，58份（68.2%）没有铁。所呈现的数据表明，缺铁性贫血在血红蛋白病患者中是常见的发现。建议在镰状细胞病的治疗中加入口服铁剂、叶酸和氯胍。
