Stenman G, Dahlenfors R, Mark J, Sandberg N
Anticancer Res. 1982 Jan-Apr;2(1-2):11-5.
Using G-banding technique, the chromosomes were studied in four consecutive preparations from cultured material from a human adenoid cystic carcinoma of the submandibular gland. The results indicated that the carcinoma had originated with a normal diploid stemline, and that reciprocal translocations played a predominant role in development of an abnormal stemline. The propensity of developing variant cells, as well as an abnormal stemline, characterized by various types of reciprocal translocations, was found to be a property shared by two other types of salivary gland neoplasms studied by banding techniques, namely the pleomorphic adenoma and the acinic cell tumour. The tissue of origin is suggested to be the crucial determinant responsible for this important cytogenetical similarity between different types of salivary gland tumours.
运用G显带技术，对取自下颌下腺人类腺样囊性癌培养物的连续4份制片中的染色体进行了研究。结果表明，该癌起源于正常二倍体干细胞系，并且相互易位在异常干细胞系的发展中起主要作用。通过显带技术研究发现，另外两种唾液腺肿瘤，即多形性腺瘤和腺泡细胞肿瘤，也具有产生变异细胞以及以各种相互易位为特征的异常干细胞系的倾向。组织起源被认为是导致不同类型唾液腺肿瘤之间这种重要细胞遗传学相似性的关键决定因素。
