Schnizlein C T, Bice D E, Mitchell C E, Hahn F F
Arch Environ Health. 1982 Jul-Aug;37(4):201-6. doi: 10.1080/00039896.1982.10667565.
This study describes the effect of intratracheal instillation of benzo(a)pyrene (BaP) on immunological responses in the lung-associated lymph nodes, cervical lymph nodes, and spleen after deposition of 10(8) sheep red blood cells (SRBC) in the lung or peritoneal cavity of rats. An increased number of anti-SRBC antibody-forming cells was observed in the lung-associated lymph nodes when rats were immunized simultaneously with BaP installation. A suppression in the number of anti-SRBC antibody-forming cells occurred when SRBC were given intratracheally 4 or 7 days after BaP. The effects of the BaP appeared to be on the function of the cells in the lung-associated lymph nodes rather than due to changes in the exposed lung. BaP-induced changes in antigen handling or in regulatory populations of immune cells in the lung-associated lymph nodes may be responsible for the immune alterations observed.
本研究描述了在大鼠肺或腹腔内注入10⁸个绵羊红细胞（SRBC）后，经气管内注入苯并(a)芘（BaP）对肺相关淋巴结、颈淋巴结和脾脏免疫反应的影响。当大鼠在注入BaP的同时进行免疫时，在肺相关淋巴结中观察到抗SRBC抗体形成细胞数量增加。在BaP注入后4天或7天经气管内给予SRBC时，抗SRBC抗体形成细胞数量出现抑制。BaP的作用似乎是对肺相关淋巴结中的细胞功能产生影响，而不是由于暴露的肺发生变化。BaP诱导的肺相关淋巴结中抗原处理或免疫细胞调节群体的变化可能是观察到的免疫改变的原因。
