Larsen A G, Ostvold A C, Holtlund J, Kristensen T, Laland S G
Biochem J. 1982 May 1;203(2):511-3. doi: 10.1042/bj2030511.
Zn2+ inhibits purified poly(ADP-ribose) polymerase (50% inhibition at 10 microM). Furthermore poly (ADP-ribose) polymerase present in nuclei and metaphase chromosome clusters is also inhibited by Zn2+. The inactivated enzyme could be re-activated by dithiothreitol. The concentration of Zn2+ needed to affect the enzyme activity in the organelles is sufficiently low for it to have a possible role in controlling the activity of this chromatin-bound enzyme.
锌离子可抑制纯化的聚(ADP - 核糖)聚合酶(在10微摩尔时抑制率达50%)。此外,存在于细胞核和中期染色体簇中的聚(ADP - 核糖)聚合酶也会受到锌离子的抑制。失活的酶可被二硫苏糖醇重新激活。影响细胞器中该酶活性所需的锌离子浓度足够低,使其有可能在控制这种与染色质结合的酶的活性方面发挥作用。