新型聚（ADP - 核糖）合成酶抑制剂
Novel inhibitors of poly(ADP-ribose) synthetase.
作者信息
Purnell M R, Whish W J
出版信息
Biochem J. 1980 Mar 1;185(3):775-7. doi: 10.1042/bj1850775.
Abstract
In a search for new inhibitors of the nuclear enzyme poly(ADP-ribose) synthetase, it was found that various benzamides substituted in the 3-position were the most inhibitory compounds found to date. Two of the benzamides, 3-aminobenzamide and 3-methoxybenzamide, were found to be competitive inhibitors, with Ki values or less than 2 microM.
摘要
在寻找核酶聚（ADP - 核糖）合成酶的新抑制剂的过程中，发现3位被取代的各种苯甲酰胺是迄今为止发现的最具抑制性的化合物。其中两种苯甲酰胺，即3 - 氨基苯甲酰胺和3 - 甲氧基苯甲酰胺，被发现是竞争性抑制剂，其抑制常数（Ki）值小于2微摩尔。
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Specific inhibition of poly adpribose polymerase by thymidine and nicotinamide in HeLa cells.胸腺嘧啶核苷和烟酰胺对HeLa细胞中聚ADP核糖聚合酶的特异性抑制作用
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Inhibition of nuclear NAD nucleosidase and poly ADP-ribose polymerase activity from rat liver by nicotinamide and 5'-methyl nicotinamide.烟酰胺和5'-甲基烟酰胺对大鼠肝脏中核NAD核苷酶和聚ADP-核糖聚合酶活性的抑制作用。
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