Srivastava S K, Ansari N H, Brown J H, Petrash J M
Biochim Biophys Acta. 1982 Aug 6;717(2):210-4. doi: 10.1016/0304-4165(82)90171-4.
Formation of sorbitol 6-phosphate by bovine and human lens aldose reductase and sorbitol dehydrogenase by the reduction of glucose 6-phosphate and fructose 6-phosphate, respectively, has been demonstrated. The reaction product has been identified by Dowex-formate column chromatography, gas chromatography and mass spectrometry. Sorbitol 6-phosphate can also be formed by the phosphorylation of sorbitol by lens sorbitol kinase in the presence of ATP.
已经证实，牛和人晶状体醛糖还原酶分别通过还原6-磷酸葡萄糖和6-磷酸果糖形成6-磷酸山梨醇，以及山梨醇脱氢酶。反应产物已通过Dowex-甲酸盐柱色谱法、气相色谱法和质谱法进行鉴定。在ATP存在的情况下，晶状体山梨醇激酶也可通过山梨醇的磷酸化形成6-磷酸山梨醇。
