Zimmer R, Cramer H, Athen D, Beckmann H
Biol Psychiatry. 1982 Jul;17(7):837-43.
In eight patients with a history of alcoholism (on average 9 years), cyclic 3',5'-monophosphate (AMP) and cyclic 3',5'-monophosphate (GMP) were determined in CSF in the acute untreated phase of delirium tremens and at 2 weeks later when clinical symptoms had vanished. Before the second lumbar puncture a drug-free period of 1 week had existed. The results were compared with an age- and sex-matched neurological control group. CSF cyclic AMP concentrations were markedly reduced by 62% (p less than 0.005) in the acute state of delirium tremens and remained at the same level 2 weeks later; cyclic GMP concentrations were increased by 37% (p = 0.05) and showed a small further increase (p less than 0.05) at the second lumbar puncture. A negative correlation existed between age and cyclic AMP content of CSF (r = -0.756; p less than 0.05) in the patients group. The data indicate that the earlier observed increase in norepinephrine turnover in the acute state of delirium tremens (Athen et al., 1977) seems not to induce an increase of cyclic AMP content in CSF.
对8名有酗酒史（平均9年）的患者，在震颤谵妄未经治疗的急性期及2周后临床症状消失时，测定其脑脊液中的环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）。在第二次腰椎穿刺前有1周的停药期。将结果与年龄和性别匹配的神经科对照组进行比较。在震颤谵妄急性期，脑脊液中cAMP浓度显著降低62%（p<0.005），2周后仍维持在同一水平；cGMP浓度升高37%（p = 0.05），在第二次腰椎穿刺时进一步小幅升高（p<0.05）。患者组中年龄与脑脊液cAMP含量呈负相关（r = -0.756；p<0.05）。数据表明，早期观察到的震颤谵妄急性期去甲肾上腺素周转率增加（阿西恩等人，1977年）似乎并未导致脑脊液中cAMP含量增加。
