Gallen D D, Cowen T, Griffith S G, Haven A J, Burnstock G
Blood Vessels. 1982;19(5):237-46. doi: 10.1159/000158390.
Isolated renal arteries from newborn and adult guinea-pigs failed to respond to electrical stimulation of the intramural nerves, using parameters identical to those which elicit large neurogenic contractions in renal arteries from newborn and adult rabbits. The threshold stimulation frequency was lower and responses were greater in adult compared with neonatal rabbits. Comparisons of noradrenaline EC50 values showed that guinea-pig renal arteries are significantly less sensitive to noradrenaline that rabbit vessels. Quantitative fluorescence histochemistry of the perivascular adrenergic nerves in renal arteries revealed that the density of innervation gradually declines in the guinea-pig but substantially increases in the rabbit during postnatal development. The lack of neurogenic response of the guinea-pig renal artery, despite the existence of a varicose, adrenergic nerve plexus, is discussed.
新生和成年豚鼠的离体肾动脉对壁内神经的电刺激无反应，所使用的参数与在新生和成年兔肾动脉中引发大的神经源性收缩的参数相同。与新生兔相比，成年兔的阈刺激频率更低且反应更大。去甲肾上腺素EC50值的比较表明，豚鼠肾动脉对去甲肾上腺素的敏感性显著低于兔血管。肾动脉周围肾上腺素能神经的定量荧光组织化学显示，在出生后的发育过程中，豚鼠的神经支配密度逐渐下降，而兔的神经支配密度则大幅增加。尽管存在曲张的肾上腺素能神经丛，但豚鼠肾动脉缺乏神经源性反应的情况仍有待讨论。
