Kobayashi H, Maoret T, Spano P F, Trabucchi M
Brain Res. 1982 Jul 29;244(2):374-7. doi: 10.1016/0006-8993(82)90101-9.
The responsiveness of beta-adrenergic receptors in cerebral microvessels was studied in aged rats by measuring cAMP formation induced by norepinephrine and [125I]iodohydroxybenzylpindolol binding. The density of beta-receptor sites is reduced by aging in the rat cerebral microvessels. These results suggest that the changes in brain circulation during aging may be at least partially due to a reduction of the beta-adrenergic control of cerebral microvessels.
通过测量去甲肾上腺素诱导的环磷酸腺苷（cAMP）生成以及[125I]碘羟基苄基吲哚洛尔结合，研究了老年大鼠脑微血管中β-肾上腺素能受体的反应性。衰老会使大鼠脑微血管中β-受体位点的密度降低。这些结果表明，衰老过程中脑循环的变化可能至少部分归因于脑微血管β-肾上腺素能控制的减弱。
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