Wenzel K W
Schweiz Med Wochenschr. 1978 Mar 18;108(11):416-8.
A 58-year-old female patient with gastrointestinal complications also had primary hypothyroidism which proved therapy-resistant against high-dosage oral replacement with L-thyroxine or an L-thyroxine/L-triiodothyronine combination. Administration of four intravenous injections each of 2 mg L-thyroxine given at weekly intervals brought about a clinical and chemical euthyroid state. Thereafter it was possible to adopt an oral L-thyroxine replacement procedure without complications. Intravenous replacement of L-thyroxine and later transfer to oral medication appears a superior and safer method than the daily subcutaneous or intramuscular administration described hitherto.
一名患有胃肠道并发症的58岁女性患者还患有原发性甲状腺功能减退症，事实证明，高剂量口服左甲状腺素或左甲状腺素/三碘甲状腺原氨酸联合治疗对此无效。每周间隔静脉注射4次，每次2mg左甲状腺素，使患者达到临床和生化甲状腺功能正常状态。此后，可以采用口服左甲状腺素替代疗法，且无并发症。静脉注射左甲状腺素并随后转为口服药物治疗似乎是一种比迄今所描述的每日皮下或肌肉注射更优越、更安全的方法。
