Mattera R, Dellacha J M
Int J Pept Protein Res. 1982 Feb;19(2):181-6. doi: 10.1111/j.1399-3011.1982.tb02607.x.
Iodinated bovine growth hormone, containing no more than 1 g-atom of iodine per mole of hormone is generally used as a tracer in studies related to the action and metabolism of the hormone. This derivative was tested in different biological and immunological systems in which the hormone is known to be active. The iodinated derivative was almost indistinguishable in its properties from the native hormone when it was examined by the following criteria: body growth promoting activity, rat liver uptake in vivo, binding to rabbit liver microsomes and primary antigen-antibody interactions. Micro-complement fixation experiments suggested that the iodination produces minor alterations in the affinity of some antigenic determinants.
每摩尔激素含碘量不超过1克原子的碘化牛生长激素，通常用作与该激素作用和代谢相关研究的示踪剂。这种衍生物在已知该激素具有活性的不同生物学和免疫学系统中进行了测试。当通过以下标准进行检测时，碘化衍生物在性质上与天然激素几乎无法区分：促进身体生长的活性、体内大鼠肝脏摄取、与兔肝微粒体的结合以及一级抗原 - 抗体相互作用。微量补体结合实验表明，碘化作用会使某些抗原决定簇的亲和力发生轻微改变。
