Stengaard-Pedersen K, Schou M
Neuropharmacology. 1982 Aug;21(8):817-23. doi: 10.1016/0028-3908(82)90070-3.
The in vitro and in vivo effects of lithium ions on opiate receptor binding were studied in the cerebral cortex, the hippocampus and the basal ganglia of the rat. In vitro, lithium ions inhibited enkephalin binding to opiate receptors through a reduction in the number of binding sites, whereas the affinity was unchanged or only slightly decreased. In vivo, long term ingestion of lithium (3 weeks), during which the rats were maintained at a serum lithium level of approximately 1 mM, also inhibited enkephalin binding to rat neuronal membranes (P2-fractions) through a reduction of the number of opiate receptor binding sites, whereas the affinity was unchanged. No lithium could be detected in the suspension of neuronal membranes from the lithium-treated rats, and no difference in the concentration of endogenous opioid peptides was found between control rats and lithium-treated rats. The opiate receptors from control rats and lithium-treated rats did no display any difference in lithium sensitivity. This data suggest that administration of lithium to rats in small doses reduces opiate receptor binding of enkephalin.
研究了锂离子对大鼠大脑皮层、海马体和基底神经节中阿片受体结合的体外和体内效应。在体外，锂离子通过减少结合位点数量来抑制脑啡肽与阿片受体的结合，而亲和力不变或仅略有降低。在体内，长期摄入锂（3周），在此期间大鼠血清锂水平维持在约1 mM，也通过减少阿片受体结合位点数量来抑制脑啡肽与大鼠神经元膜（P2组分）的结合，而亲和力不变。在锂处理大鼠的神经元膜悬液中未检测到锂，且对照大鼠和锂处理大鼠之间内源性阿片肽浓度无差异。对照大鼠和锂处理大鼠的阿片受体在锂敏感性方面未显示任何差异。这些数据表明，给大鼠小剂量施用锂会降低脑啡肽的阿片受体结合。
