De A K, Aiyar A S
Strahlentherapie. 1978 Feb;154(2):134-8.
Whole-body irradiation of rats at sublethal doses leads to hepatic lipid accumulation which reaches a maximum by the sixth day; this effect on lipid metabolism does not appear to be due to accompanying inanition but due to irradiation per se. The female rats show a greater and more consistent increase in liver lipids than males and this better response of the females is not abolished by prolonged administration of testosterone to these animals. An accumulation of triglycerides accounts for almost all the increases in total liver lipids, although smaller elevations in the levels of free fatty acids and cholesterol are also seen. Free fatty acids of liver show a marked decrease on the second day following irradiation. Serum lipids do not show any appreciable changes while adipose lipids progressively decrease reaching a minimum by the sixth day. Although an insufficiency of ATP may be responsible for lipid accumulation in the irradiated rat as is the case in rats treated with ethionine or orotic acid, adenine administration, which prevents fatty infiltration due to these chemical agents, does not protect against the radiation-induced increase in liver triglycerides.
以亚致死剂量对大鼠进行全身照射会导致肝脏脂质积累，这种积累在第六天达到最大值；这种对脂质代谢的影响似乎不是由于伴随的营养缺乏，而是由于照射本身。雌性大鼠肝脏脂质的增加比雄性大鼠更显著且更一致，并且给这些动物长期注射睾酮并不会消除雌性大鼠的这种更好的反应。甘油三酯的积累几乎占肝脏总脂质增加的全部，尽管游离脂肪酸和胆固醇水平也有较小幅度的升高。肝脏中的游离脂肪酸在照射后的第二天显著下降。血清脂质没有明显变化，而脂肪脂质逐渐减少，在第六天达到最小值。尽管三磷酸腺苷（ATP）不足可能像在接受乙硫氨酸或乳清酸处理的大鼠中一样，是照射大鼠脂质积累的原因，但给予腺嘌呤可防止这些化学物质引起的脂肪浸润，却不能防止辐射诱导的肝脏甘油三酯增加。
