[Aspects of dysmicrobism in the isolation of Koch bacilli and its pathological implications].

The results are presented, of a follow-up over several years concerning the changes which occurred in the products sampled from tuberculous patients, with regard to the ecologic balance between Mycobacterium tuberculosis, and other mycobacteria and fungi under the influences of chemical drugs and antibiotics. Thus atypical mycobacteria have been recorded, in a proportion of 1.07% (and in some periods as high as 2.52%). Other species were also identified, classified according to morphological and chemical characteristics. These species are included in a synoptic scheme used in laboratories which are concerned with the isolation of mycobacteria. At present different species of mycobacteria can be isolated on the same culture medium, as appears also from the results of the authors of this study. Beside manifestations of dysmicrobism another fact was also demonstrated, namely the frequent isolation of fungi in patients undergoing anti-tuberculous therapy, or secondary to the anti-tuberculous treatment. This has permitted, on the basis of the authors' cases to confirm some pulmonary mycoses according to generally accepted rigorous laboratory techniques. The present study stresses the new pathologic phenomena interrelated with tuberculosis. These data expand the knowledge of laboratory techniques and methods, and improve cooperation between laboratories and clinical units involved in the diagnosis and treatment of pulmonary affections.