Jacquet Y F, Abrams G M
Science. 1982 Oct 8;218(4568):175-7. doi: 10.1126/science.6289433.
A unilateral microinjection of adrenocorticotropin 1-24 in the rat brainstem in the region of the locus ceruleus resulted in postural asymmetry and movement disorder that resembled human dystonia, the severity and duration (2 to 3 days) being dose-dependent. These results show for the first time that neuropeptides in the brainstem may modulate posture and movement, and they suggest that some forms of movement disorder such as dystonia may be due to a disordered regulation of postural and locomotor mechanisms by adrenocorticotropin 1-24.
在大鼠脑干蓝斑区域单侧微量注射促肾上腺皮质激素1 - 24，会导致姿势不对称和运动障碍，类似于人类肌张力障碍，其严重程度和持续时间（2至3天）呈剂量依赖性。这些结果首次表明，脑干中的神经肽可能调节姿势和运动，并且提示某些形式的运动障碍，如肌张力障碍，可能是由于促肾上腺皮质激素1 - 24对姿势和运动机制的调节紊乱所致。
