Rouëssé J, Kalifa C, Genin J, Lemerle J, Sarrazin D
Sem Hop. 1982 Jul 8;58(28-29):1678-80.
The European Organization for Research on the Treatment of Cancer (EORTC) and the international Society of Pediatric Oncology (ISPO) have set up a randomized controlled trial designed to compare three different regimens of adjuvant therapy applied after treatment of the primary tumor (usually by radical surgery): a prolonged course of chemotherapy (41 weeks) combining adriamycin, methotrexate in high doses followed by folinic acid, vincristine, and cyclophosphamide; radiotherapy delivering 20 grays to the lungs; and a short course of chemotherapy (8 weeks) combining adriamycin, methotrexate in high doses, folinic acid and vincristine, associated with irradiation of the lungs as in the preceding protocol. At the time being, 156 patients have been included in this study. If conclusions are to be drawn from this trial, a total of 300 patients seems necessary.
欧洲癌症研究与治疗组织（EORTC）和国际儿科肿瘤学会（ISPO）开展了一项随机对照试验，旨在比较原发性肿瘤治疗（通常采用根治性手术）后应用的三种不同辅助治疗方案：一种是化疗疗程延长（41周），联合阿霉素、大剂量甲氨蝶呤随后用亚叶酸、长春新碱和环磷酰胺；一种是对肺部进行20格雷的放射治疗；还有一种是化疗疗程较短（8周），联合阿霉素、大剂量甲氨蝶呤、亚叶酸和长春新碱，并与前一方案一样对肺部进行照射。目前，已有156名患者纳入该研究。若要从该试验得出结论，似乎需要总共300名患者。
