大鼠突触体细胞膜和尾状核匀浆中的腺苷酸环化酶：多巴胺、E型前列腺素、鸟苷-5'-基-亚氨基二磷酸和吗啡的作用。

Adenylate cyclase in rat synaptosomal plasma membranes and caudate nucleus homogenate: effects of dopamine, E prostaglandins, guanyl-5'-yl-imidodiphosphate and morphine.

作者信息

Grynne B H

出版信息

Acta Pharmacol Toxicol (Copenh). 1982 Jul;51(1):51-6. doi: 10.1111/j.1600-0773.1982.tb01062.x.

DOI:10.1111/j.1600-0773.1982.tb01062.x

Abstract

The adenylate cyclase in two particulate preparations from rat brain, a homogenate from caudate nucleus (CN-homogenate) and a synaptosomal plasma membrane fraction (SPM-fraction) from whole rat brain was investigated. Stimulation of the enzyme by dopamine and prostaglandins E1 and E2 was found in the CN-homogenate while only a weak prostaglandin E1 and E2 stimulation and no dopamine stimulation could be found in the SPM-fraction. Guanyl-5'-yl-imidophosphate (GppNHp) and NaF could stimulate the adenylate cyclase in both preparations. Morphine up to 10(-5) M altered neither the basal enzyme activity nor any of the stimulated enzyme activities.

摘要

对大鼠脑的两种颗粒制剂中的腺苷酸环化酶进行了研究，这两种制剂分别是尾状核匀浆（CN匀浆）和全大鼠脑的突触体细胞膜部分（SPM部分）。在CN匀浆中发现多巴胺以及前列腺素E1和E2可刺激该酶，而在SPM部分中仅发现前列腺素E1和E2有微弱刺激作用，未发现多巴胺刺激作用。鸟苷-5'-基-亚氨二磷酸（GppNHp）和氟化钠可刺激两种制剂中的腺苷酸环化酶。高达10(-5) M的吗啡既不改变基础酶活性，也不改变任何刺激后的酶活性。

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