Liver and prostate adenocarcinoma: an "estrogen-free" environment?

We believe that the probable "estrogen-free" site which is present in the liver while a patient is on estrogens gives a conductive environment for local growth of prostate malignancy. We report 1 patient who improved with local irradiation and 2 others who stabilized and symptomatically improved with chemotherapy. Hopefully, future reports will shed more light on the treatment of hepatic metastases from prostatic adenocarcinoma.