Facchinetti F, Nappi G, Savoldi F, Genazzani A R
Cephalalgia. 1981 Dec;1(4):195-201. doi: 10.1046/j.1468-2982.1981.0104195.x.
Eleven patients affected by common migraine (CM), eleven affected by daily chronic headache (DCH), and eight healthy volunteers were studied. Plasma levels of beta-endorphin (beta EP), beta-lipotropin (beta LPH). ACTH and cortisol were measured in basal conditions and after traditional Chinese acupuncture (TCA). Basal beta LPH and beta EP plasma levels (pg/ml) in the DCH patients (57.6 +/- 9.5 and 16.8 +/- 2.5, respectively; M +/- SE) were lower than those found in the controls (83.6 +/- 13.7 and 26.0 +/- 6.1; p less than 0.001), while those found in the CM cases showed inter-mediate values (75.3 +/- 12.0 and 24.4 +/- 5.8). ACTH and cortisol concentrations in both the CM and DCH patients were in the same range as those of the control group. TCA caused an increase in beta LPH and beta EP plasma concentrations in the control group (beta LPH: 117 +/- 16.9; beta EP: 44.1 +/- 6.7). Opioid plasma levels, however, remained unmodified after TCA in both the CM and DCH groups. ACTH plasma levels remained stable after TCA in all three subject groups. Patients suffering from primary headache are characterized by low beta LPH and beta EP plasma levels and by a poor reactivity of circulating opioids to non-stressful stimuli.
研究了11名患有普通偏头痛（CM）的患者、11名患有每日慢性头痛（DCH）的患者以及8名健康志愿者。在基础状态和传统中医针灸（TCA）后，测量了β-内啡肽（β-EP）、β-促脂素（β-LPH）、促肾上腺皮质激素（ACTH）和皮质醇的血浆水平。DCH患者的基础β-LPH和β-EP血浆水平（pg/ml）（分别为57.6±9.5和16.8±2.5；M±SE）低于对照组（83.6±13.7和26.0±6.1；p<0.001），而CM患者的水平则处于中间值（75.3±12.0和24.4±5.8）。CM和DCH患者的ACTH和皮质醇浓度与对照组处于同一范围。TCA导致对照组β-LPH和β-EP血浆浓度升高（β-LPH：117±16.9；β-EP：44.1±6.7）。然而，CM组和DCH组在TCA后阿片类血浆水平均未改变。所有三个受试者组在TCA后ACTH血浆水平均保持稳定。原发性头痛患者的特征是β-LPH和β-EP血浆水平低，以及循环阿片类物质对非应激刺激的反应性差。
