Kawashima K, Tanuma S, Endo H
Endocrinol Jpn. 1982 Apr;29(2):191-5. doi: 10.1507/endocrj1954.29.191.
The biochemical effect of a nicotinamide analogue, 6-aminonicotinamide (6-AN), on developing chick embryonic femur was studied. Growth of femur from 9-day-old embryos that had been exposed to 6-AN for 5 days in ovo was not stimulated by PTH in an in vitro culture system. PTH caused a much smaller increase in the cyclic-AMP content in 6-AN-treated femur than in control femur. However, dibutyryl cyclic-AMP stimulated growth of 6-AN-treated femur. A defect in response of 6-AN-treated femur to the growth stimulating action of PTH may explain the production of micromelia by 6-AN.
研究了烟酰胺类似物6-氨基烟酰胺（6-AN）对发育中的鸡胚股骨的生化作用。在体外培养系统中，甲状旁腺激素（PTH）并未刺激在蛋壳内暴露于6-AN 5天的9日龄胚胎的股骨生长。与对照股骨相比，PTH使6-AN处理的股骨中环状AMP含量的增加幅度小得多。然而，二丁酰环状AMP刺激了6-AN处理的股骨生长。6-AN处理的股骨对PTH生长刺激作用的反应缺陷可能解释了6-AN导致短肢畸形的原因。
