Guidet M
Nouv Presse Med. 1982 Aug 28;11(33):2506-10.
A multicentric therapeutic double blind study, conducted according to the incomplete block method and including 108 observations from 5 hospital centers, was conducted among patients suffering from acute radicular, sciatic, cervico-brachial or crural neuralgia. The purpose was to compare the analgesic effect of 4 treatments given in single dose: pirprofen 200, pirprofen 400, ketoprofen 150 and placebo. Overall analysis showed a significant decrease in pain during the 4 hours following administration of the products and in all groups. However, pirprofen 400 and ketoprofen 150 mg caused a decrease in painful phenomena, more intense than that induced by pirprofen 200 and placebo. The great heterogeneity among the different treatment centers led the investigators to carry out a second analysis limited to the 4 most homogeneous centers. This analysis, of 84 observations, shows clearly the analgesic efficacy of both doses of pirprofen and ketoprofen compared to placebo. It also emphasizes the rapidity of action of pirprofen compared to the other products. The overall tolerance of the tested products was good. In the treatment of acute radicular neuralgia, pirprofen 400 mg is active in comparison to the placebo and more quickly effective than ketoprofen 150 mg.
一项多中心治疗性双盲研究，采用不完全区组设计，纳入了来自5家医院中心的108例观察对象，研究对象为患有急性神经根性、坐骨神经、颈臂或腿部神经痛的患者。目的是比较单剂量给予的4种治疗药物的镇痛效果：200毫克吡洛芬、400毫克吡洛芬、150毫克酮洛芬和安慰剂。总体分析显示，给药后4小时内所有组的疼痛均显著减轻。然而，400毫克吡洛芬和150毫克酮洛芬引起的疼痛现象减轻程度比200毫克吡洛芬和安慰剂更明显。不同治疗中心之间存在很大的异质性，促使研究人员对4个最同质的中心进行了第二次分析。这项包含84例观察对象的分析清楚地表明，与安慰剂相比，两种剂量的吡洛芬和酮洛芬均具有镇痛效果。它还强调了吡洛芬与其他产品相比起效更快。受试产品的总体耐受性良好。在急性神经根性神经痛的治疗中，400毫克吡洛芬与安慰剂相比有活性，且比150毫克酮洛芬起效更快。
