Gawade S P, Gaitonde B B
Toxicon. 1982;20(4):797-801. doi: 10.1016/0041-0101(82)90128-3.
Three neurotoxic components, enhydrotoxins a, b and c, were isolated by a three step procedure from the venom of the sea snake Enhydrina schistosa, caught in the Arabian sea. The i.v. LD50 values in mice were 0.042, 0.045 and 0.052 mg/kg, respectively. All three toxins irreversibly blocked neuromuscular transmission. Abolition of responses to acetylcholine indicated a post-synaptic site of action of these toxins. The molecular weight and amino acid composition of enhydrotoxin a are similar to values earlier reported for Enhydrina toxins.
通过三步分离程序，从捕获于阿拉伯海的裂颏海蛇（Enhydrina schistosa）的毒液中分离出三种神经毒性成分，即水合毒素a、b和c。这些毒素对小鼠的静脉注射半数致死量（LD50）分别为0.042、0.045和0.052毫克/千克。所有这三种毒素均不可逆地阻断神经肌肉传递。对乙酰胆碱反应的消失表明这些毒素的作用位点在突触后。水合毒素a的分子量和氨基酸组成与先前报道的裂颏海蛇毒素的值相似。
