通过冰中HCN低聚作用进行益生元腺嘌呤合成。

Prebiotic adenine synthesis via HCN oligomerization in ice.

作者信息

Schwartz A W, Joosten H, Voet A B

出版信息

Biosystems. 1982;15(3):191-3. doi: 10.1016/0303-2647(82)90003-x.

Abstract

Adenine is produced (after hydrolysis) when 0.01 M solutions of HCN are adjusted to pH 9.2 with NH4OH and are frozen at -2 degrees C for 60-100 days. The addition of glycolonitrile (the cyanohydrin of formaldehyde) increases the yield of adenine under these conditions by about five-fold. These results confirm and extend an earlier suggestion that purine synthesis on the prebiotic Earth might have occurred in frozen, dilute solutions of HCN.

摘要

当用氢氧化铵将0.01M的氢氰酸溶液调节至pH 9.2并在-2℃下冷冻60 - 100天时，（水解后）会产生腺嘌呤。在这些条件下，添加乙醇腈（甲醛的氰醇）可使腺嘌呤的产量提高约五倍。这些结果证实并扩展了早期的一个观点，即前生物地球时期嘌呤的合成可能发生在冷冻的、稀释的氢氰酸溶液中。